OBJECTIVE To prepare a novel brain targeting system, lactoferrin conjugated self-assembled polymer vesicles ( Lf-PVs), which the brain delivery property had been evaluated in vivo. 目的构建以乳铁蛋白作为靶向功能基、可生物降解聚合物泡囊为载体的脑靶向递药系统,并对其脑部递药特性作出药效学评价。
Preparation and evaluation of brain delivery property of lactoferrin conjugated self-assembled Polymer vesicles loaded 6-coumarin in vitro 自组装乳铁蛋白-聚合物泡囊载香豆素-6的体外脑递药特性研究
The three brain vesicles were observed at the 6th day of incubation. 胚胎孵育第6d,三个脑泡明显;
Brain microvascular endothelial cells are characterized by the presence of tight junctions and the absence of fenestrations and vesicles. 脑毛细血管内皮细胞以紧密连接为特点,缺乏窗孔和胞饮泡。
After brain ischemia, the tight junctions of BBB are disrupted, transcytosis vesicles are increased, and leukocytes adherence and migration rate is enhanced. 脑缺血后,血脑屏障间紧密连接破坏,胞饮小泡数量增加,白细胞粘附迁移率增加。